Karp says you probably will need to continue the cuddle cure after baby is settled, and even after baby has fallen asleep (page 189).
Karp says that if the cuddle cure is not working for your baby, first make sure you are doing the 5 S's correctly. See The Happiest Baby on the Block to review the 5 S's; however, if you have a colicky baby and are wanting to use these methods to soothe your baby, please do not rely on the posts on this blog. These are intended as a review so you can know if it is a book you want to purchase or not. Also, I know I say this a lot, but you might be more interested in the DVD than the book, especially if you learn better by watching someone do it than by reading about how to do it.
Once you are sure you have the method down, Karp encourages you to practice. He says it is good to practice on a doll or on your baby while he is calm (page 192). Through practice, he states both you and your baby will get better at the Cuddle Cure.